Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells

Neuroblastoma is the most commonly diagnosed extracranial tumor in the first year of life. Approximately 9% of neuroblastoma patients present germline or somatic aberrations in the gene encoding for anaplastic lymphoma kinase (ALK). This increases in high-risk neuroblastomas, which have a 14% freque...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Cervantes-Madrid, Diana, Szydzik, Joanna, Lind, Dan Emil, Borenäs, Marcus, Bemark, Mats, Cui, Jean, Palmer, Ruth Helen, Hallberg, Bengt
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920469/
https://ncbi.nlm.nih.gov/pubmed/31852910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55060-7
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