Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses

The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglobulin G (IgG). Recently, several clinical studies have reported the lowering of circulating monomeric IgG levels through FcRn blockade for the potential treatment of autoimmune disease...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Blumberg, L. J., Humphries, J. E., Jones, S. D., Pearce, L. B., Holgate, R., Hearn, A., Cheung, J., Mahmood, A., Del Tito, B., Graydon, J. S., Stolz, L. E., Bitonti, A., Purohit, S., de Graaf, D., Kacena, K., Andersen, J. T., Christianson, G. J., Roopenian, D. C., Hubbard, J. J., Gandhi, A. K., Lasseter, K., Pyzik, M., Blumberg, R. S.
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920022/
https://ncbi.nlm.nih.gov/pubmed/31897428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9586
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