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Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses
The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglobulin G (IgG). Recently, several clinical studies have reported the lowering of circulating monomeric IgG levels through FcRn blockade for the potential treatment of autoimmune disease...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6920022/ https://ncbi.nlm.nih.gov/pubmed/31897428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9586 |
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