Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

In Alzheimer’s disease (AD), spliceosomal proteins with critical roles in RNA processing aberrantly aggregate and mislocalize to Tau neurofibrillary tangles. We test the hypothesis that Tau-spliceosome interactions disrupt pre-mRNA splicing in AD. In human postmortem brain with AD pathology, Tau coi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Hsieh, Yi-Chen, Guo, Caiwei, Yalamanchili, Hari K., Abreha, Measho, Al-Ouran, Rami, Li, Yarong, Dammer, Eric B., Lah, James J., Levey, Allan I., Bennett, David A., De Jager, Philip L., Seyfried, Nicholas T., Liu, Zhandong, Shulman, Joshua M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919331/
https://ncbi.nlm.nih.gov/pubmed/31597093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.104
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