Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

In Alzheimer’s disease (AD), spliceosomal proteins with critical roles in RNA processing aberrantly aggregate and mislocalize to Tau neurofibrillary tangles. We test the hypothesis that Tau-spliceosome interactions disrupt pre-mRNA splicing in AD. In human postmortem brain with AD pathology, Tau coi...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Hsieh, Yi-Chen, Guo, Caiwei, Yalamanchili, Hari K., Abreha, Measho, Al-Ouran, Rami, Li, Yarong, Dammer, Eric B., Lah, James J., Levey, Allan I., Bennett, David A., De Jager, Philip L., Seyfried, Nicholas T., Liu, Zhandong, Shulman, Joshua M.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919331/
https://ncbi.nlm.nih.gov/pubmed/31597093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.104
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