Lot-to-Lot Variation in Adeno-Associated Virus Serotype 9 (AAV9) Preparations

Viral vectors are complex drugs that pose a particular challenge for manufacturing. Previous studies have shown that, unlike small-molecule drugs, vector preparations do not yield a collection of identical particles. Instead, a mixture of particles that vary in capsid stoichiometry and impurities is...

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Bibliographic Details
Published in:Hum Gene Ther Methods
Main Authors: O'Connor, Deirdre M., Lutomski, Corinne, Jarrold, Martin F., Boulis, Nicholas M., Donsante, Anthony
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc., publishers 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919242/
https://ncbi.nlm.nih.gov/pubmed/31752530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2019.105
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