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NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities

Human cell reprogramming remains extremely inefficient and the underlying mechanisms by different reprogramming factors are elusive. We found that NANOG and LIN28 (NL) synergize to improve OCT4, SOX2, KLF4 and MYC (OSKM)-mediated reprogramming by ∼76-fold and shorten reprogramming latency by at leas...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Wang, Ling, Su, Yue, Huang, Chang, Yin, Yexuan, Chu, Alexander, Knupp, Alec, Tang, Young
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918770/
https://ncbi.nlm.nih.gov/pubmed/31806618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.047225
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