A Xenograft Model to Evaluate the Bone Forming Effects of Sclerostin Antibody in Human Bone Derived from Pediatric Osteogenesis Imperfecta Patients

Osteogenesis imperfecta (OI) is a rare and severe skeletal dysplasia marked by low bone mass and poor bone quality which is especially burdensome during childhood. Since clinical trials for pediatric OI are difficult, there is a widespread reliance on genetically modified murine models to understand...

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Udgivet i:Bone
Main Authors: Surowiec, Rachel K, Battle, Lauren F, Ward, Ferrous S, Schlecht, Stephen H, Khoury, Basma M, Robbins, Christopher, Wojtys, Edward M., Caird, Michelle S, Kozloff, Kenneth M
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6918492/
https://ncbi.nlm.nih.gov/pubmed/31678490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.115118
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