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Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations
Recent work demonstrated the propensity of dopamine transporters (DATs) to form trimers or higher oligomers, enhanced upon binding a furopyrimidine, AIM-100. AIM-100 binding promotes DAT endocytosis and thereby moderates dopaminergic transmission. Despite the neurobiological significance of these ev...
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| Veröffentlicht in: | Neuropharmacology |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6917874/ https://ncbi.nlm.nih.gov/pubmed/31228486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.107676 |
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