Systematic underestimation of the epigenetic clock and age acceleration in older subjects

BACKGROUND: The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments. RESULTS: The model systematically underestimates age in tiss...

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Опубликовано в: :Genome Biol
Главные авторы: El Khoury, Louis Y., Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915902/
https://ncbi.nlm.nih.gov/pubmed/31847916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1810-4
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