Systematic underestimation of the epigenetic clock and age acceleration in older subjects

BACKGROUND: The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments. RESULTS: The model systematically underestimates age in tiss...

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Detalles Bibliográficos
Publicado en:Genome Biol
Main Authors: El Khoury, Louis Y., Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915902/
https://ncbi.nlm.nih.gov/pubmed/31847916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1810-4
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