An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAF(V600) mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that e...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Shen, Shensi, Faouzi, Sara, Bastide, Amandine, Martineau, Sylvain, Malka-Mahieu, Hélène, Fu, Yu, Sun, Xiaoxiao, Mateus, Christine, Routier, Emilie, Roy, Severine, Desaubry, Laurent, André, Fabrice, Eggermont, Alexander, David, Alexandre, Scoazec, Jean-Yves, Vagner, Stéphan, Robert, Caroline
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915789/
https://ncbi.nlm.nih.gov/pubmed/31844050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13360-6
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