Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

Antimicrobial peptides (AMPs) are key effectors of the innate immune system and promising therapeutic agents. Yet, knowledge on how to design AMPs with minimal cross-resistance to human host-defense peptides remains limited. Here, we systematically assess the resistance determinants of Escherichia c...

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Udgivet i:Nat Commun
Main Authors: Kintses, Bálint, Jangir, Pramod K., Fekete, Gergely, Számel, Mónika, Méhi, Orsolya, Spohn, Réka, Daruka, Lejla, Martins, Ana, Hosseinnia, Ali, Gagarinova, Alla, Kim, Sunyoung, Phanse, Sadhna, Csörgő, Bálint, Györkei, Ádám, Ari, Eszter, Lázár, Viktória, Nagy, István, Babu, Mohan, Pál, Csaba, Papp, Balázs
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915728/
https://ncbi.nlm.nih.gov/pubmed/31844052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13618-z
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