Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

Antimicrobial peptides (AMPs) are key effectors of the innate immune system and promising therapeutic agents. Yet, knowledge on how to design AMPs with minimal cross-resistance to human host-defense peptides remains limited. Here, we systematically assess the resistance determinants of Escherichia c...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Kintses, Bálint, Jangir, Pramod K., Fekete, Gergely, Számel, Mónika, Méhi, Orsolya, Spohn, Réka, Daruka, Lejla, Martins, Ana, Hosseinnia, Ali, Gagarinova, Alla, Kim, Sunyoung, Phanse, Sadhna, Csörgő, Bálint, Györkei, Ádám, Ari, Eszter, Lázár, Viktória, Nagy, István, Babu, Mohan, Pál, Csaba, Papp, Balázs
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915728/
https://ncbi.nlm.nih.gov/pubmed/31844052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13618-z
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