Assessing average somatic CAG repeat instability at the protein level

Sandwich ELISA-based methods use Abs that target the expanded polyglutamine (polyQ) tract to quantify mutant huntingtin (mHTT). Using Meso Scale Discovery (MSD) assay, the mHTT signal detected with MW1 Ab correlated with polyQ length and doubled with a difference of only 7 glutamine residues between...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Aviolat, Hubert, Pinto, Ricardo Mouro, Godschall, Elizabeth, Murtha, Ryan, Richey, Hannah E., Sapp, Ellen, Vodicka, Petr, Wheeler, Vanessa C., Kegel-Gleason, Kimberly B., DiFiglia, Marian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915696/
https://ncbi.nlm.nih.gov/pubmed/31844074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55202-x
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