Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central component of mTORC1 and alters the kinetics of excitatory synaptic transmis...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kouloulia, Stella, Hallin, Erik I., Simbriger, Konstanze, Amorim, Inês S., Lach, Gilliard, Amvrosiadis, Theoklitos, Chalkiadaki, Kleanthi, Kampaite, Agniete, Truong, Vinh Tai, Hooshmandi, Mehdi, Jafarnejad, Seyed Mehdi, Skehel, Paul, Kursula, Petri, Khoutorsky, Arkady, Gkogkas, Christos G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915327/
https://ncbi.nlm.nih.gov/pubmed/31825840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.023
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