Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central component of mTORC1 and alters the kinetics of excitatory synaptic transmis...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Kouloulia, Stella, Hallin, Erik I., Simbriger, Konstanze, Amorim, Inês S., Lach, Gilliard, Amvrosiadis, Theoklitos, Chalkiadaki, Kleanthi, Kampaite, Agniete, Truong, Vinh Tai, Hooshmandi, Mehdi, Jafarnejad, Seyed Mehdi, Skehel, Paul, Kursula, Petri, Khoutorsky, Arkady, Gkogkas, Christos G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915327/
https://ncbi.nlm.nih.gov/pubmed/31825840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.023
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