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Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

Misfolded proteins in the lumen of the endoplasmic reticulum (ER) are retrotranslocated into the cytosol and polyubiquitinated before being degraded by the proteasome. The multi-spanning ubiquitin ligase Hrd1 forms the retrotranslocation channel and associates with three other membrane proteins (Hrd...

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Pubblicato in:eLife
Autori principali: Peterson, Brian G, Glaser, Morgan L, Rapoport, Tom A, Baldridge, Ryan D
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6914336/
https://ncbi.nlm.nih.gov/pubmed/31713515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50903
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