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Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD
Misfolded proteins of the endoplasmic reticulum (ER) are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded...
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| Pubblicato in: | Cell |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4946995/ https://ncbi.nlm.nih.gov/pubmed/27321670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.048 |
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