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Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD

Misfolded proteins of the endoplasmic reticulum (ER) are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded...

詳細記述

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書誌詳細
出版年:Cell
主要な著者: Baldridge, Ryan D., Rapoport, Tom A.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946995/
https://ncbi.nlm.nih.gov/pubmed/27321670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.048
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