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Retro-translocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
Misfolded, luminal endoplasmic reticulum (ER) proteins are retro-translocated into the cytosol and degraded by the ubiquitin/proteasome system. This ERAD-L pathway requires a protein complex consisting of the ubiquitin ligase Hrd1p, which spans the ER membrane multiple times, and the membrane protei...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026631/ https://ncbi.nlm.nih.gov/pubmed/21074049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.10.028 |
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