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Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex
Misfolded luminal endoplasmic reticulum (ER) proteins undergo ER-associated degradation (ERAD-L): they are retro-translocated into the cytosol, poly-ubiquitinated, and degraded by the proteasome. ERAD-L is mediated by the Hrd1 complex (composed of Hrd1, Hrd3, Der1, Usa1, and Yos9), but the mechanism...
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| Izdano u: | Science |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7380553/ https://ncbi.nlm.nih.gov/pubmed/32327568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz2449 |
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