The hyaluronidase, TMEM2, promotes ER homeostasis and longevity independent of the UPR(ER)

Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPR(ER), which are strongly associated with several diseases and the aging process. We performed a whole genome CRISPR-based knockout screen to identify genes important for cells to survive ER-based protein misfolding...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Schinzel, Robert Thomas, Higuchi-Sanabria, Ryo, Shalem, Ophir, Moehle, Erica Ann, Webster, Brant Michael, Joe, Larry, Bar-Ziv, Raz, Frankino, Phillip Andrew, Durieux, Jenni, Pender, Corinne, Kelet, Naame, Kumar, Saranya Santhosh, Savalia, Nupur, Chi, Hannah, Simic, Milos, Nguyen, Ngoc-Tram, Dillin, Andrew
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913896/
https://ncbi.nlm.nih.gov/pubmed/31761535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.10.018
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