The hyaluronidase, TMEM2, promotes ER homeostasis and longevity independent of the UPR(ER)

Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPR(ER), which are strongly associated with several diseases and the aging process. We performed a whole genome CRISPR-based knockout screen to identify genes important for cells to survive ER-based protein misfolding...

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Gepubliceerd in:Cell
Hoofdauteurs: Schinzel, Robert Thomas, Higuchi-Sanabria, Ryo, Shalem, Ophir, Moehle, Erica Ann, Webster, Brant Michael, Joe, Larry, Bar-Ziv, Raz, Frankino, Phillip Andrew, Durieux, Jenni, Pender, Corinne, Kelet, Naame, Kumar, Saranya Santhosh, Savalia, Nupur, Chi, Hannah, Simic, Milos, Nguyen, Ngoc-Tram, Dillin, Andrew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913896/
https://ncbi.nlm.nih.gov/pubmed/31761535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.10.018
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