Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord

Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents axons from re-entering the midline. In insects and mammals, negative regulation of Roundabout (Robo) receptors prevents premature response to t...

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Vydáno v:Cell Rep
Hlavní autoři: Gorla, Madhavi, Santiago, Celine, Chaudhari, Karina, Layman, Awo Akosua Kesewa, Oliver, Paula M., Bashaw, Greg J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913780/
https://ncbi.nlm.nih.gov/pubmed/30893602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.080
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