Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord

Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents axons from re-entering the midline. In insects and mammals, negative regulation of Roundabout (Robo) receptors prevents premature response to t...

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Udgivet i:Cell Rep
Main Authors: Gorla, Madhavi, Santiago, Celine, Chaudhari, Karina, Layman, Awo Akosua Kesewa, Oliver, Paula M., Bashaw, Greg J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913780/
https://ncbi.nlm.nih.gov/pubmed/30893602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.080
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