Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor Commissureless, which reduces surface expressio...

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Bibliographic Details
Published in:eLife
Main Authors: Evans, Timothy A, Santiago, Celine, Arbeille, Elise, Bashaw, Greg J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Developmental Biology and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505356/
https://ncbi.nlm.nih.gov/pubmed/26186094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08407
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