Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

Influenza A virus (IAV) and influenza B virus (IBV) cause yearly epidemics with significant morbidity and mortality. When zoonotic IAVs enter the human population, the viral hemagglutinin (HA) requires adaptation to achieve sustained virus transmission. In contrast, IBV has been circulating in human...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Laporte, Manon, Stevaert, Annelies, Raeymaekers, Valerie, Boogaerts, Talitha, Nehlmeier, Inga, Chiu, Winston, Benkheil, Mohammed, Vanaudenaerde, Bart, Pöhlmann, Stefan, Naesens, Lieve
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912116/
https://ncbi.nlm.nih.gov/pubmed/31597759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01430-19
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