Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

RNA dysregulation likely contributes to disease pathogenesis of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. A pathological form of the transactive response (TAR) DNA binding protein (TDP-43) binds to RNA in stress granules and forms membraneless, amyloid-like TDP-43 agg...

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Vydáno v:ACS Chem Biol
Hlavní autoři: François-Moutal, Liberty, Felemban, Razaz, Scott, David D., Sayegh, Melissa R., Miranda, Victor G., Perez-Miller, Samantha, Khanna, Rajesh, Gokhale, Vijay, Zarnescu, Daniela C., Khanna, May
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911355/
https://ncbi.nlm.nih.gov/pubmed/31241884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00481
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