Enterotoxins can support CAR T cells against solid tumors

Responses of solid tumors to chimeric antigen receptor (CAR) T cell therapy are often minimal. This is potentially due to a lack of sustained activation and proliferation of CAR T cells when encountering antigen in a profoundly immunosuppressive tumor microenvironment. In this study, we investigate...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: von Scheidt, Bianca, Wang, Minyu, Oliver, Amanda J., Chan, Jack D., Jana, Metta K., Ali, Aesha I., Clow, Fiona, Fraser, John D., Quinn, Kylie M., Darcy, Phillip K., Kershaw, Michael H., Slaney, Clare Y.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911243/
https://ncbi.nlm.nih.gov/pubmed/31767744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904618116
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