Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance

Emtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors (NRTIs) in anti-HIV therapy. Treatment with FTC or 3TC primarily selects for the HIV-1 RT M184V/I resistance mutations. Here we pro...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Hung, Magdeleine, Tokarsky, E. John, Lagpacan, Leanna, Zhang, Lijun, Suo, Zucai, Lansdon, Eric B.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910994/
https://ncbi.nlm.nih.gov/pubmed/31872074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0706-x
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