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Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
Npl4 is likely to be the most upstream factor recognizing Lys48-linked polyubiquitylated substrates in the proteasomal degradation pathway in yeast. Along with Ufd1, Npl4 forms a heterodimer (UN), and functions as a cofactor for the Cdc48 ATPase. Here, we report the crystal structures of yeast Npl4...
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| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6910952/ https://ncbi.nlm.nih.gov/pubmed/31836717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13697-y |
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