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Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

The RhoGTPases are characterized as membrane-associated molecular switches that cycle between active, GTP-bound and inactive, GDP-bound states. However, 90–95% of RhoGTPases are maintained in a soluble form by RhoGDI, which is generally viewed as a passive shuttle for inactive RhoGTPases. Our curren...

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Pubblicato in:eLife
Autori principali: Golding, Adriana E, Visco, Ilaria, Bieling, Peter, Bement, William M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910828/
https://ncbi.nlm.nih.gov/pubmed/31647414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50471
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