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Regulation of RhoGTPase crosstalk, degradation and activity by RhoGDI1

At steady state, most Rho GTPases are bound in the cytosol to Rho Guanine nucleotide Dissociation Inhibitors (RhoGDI) 1. RhoGDIs have generally been considered to passively hold Rho proteins in an inactive state within the cytoplasm. Here we describe an evolutionarily conserved mechanism by which Rh...

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Autori principali: Boulter, Etienne, Garcia-Mata, Rafael, Guilluy, Christophe, Dubash, Adi, Rossi, Guendalina, Brennwald, Patrick J., Burridge, Keith
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866742/
https://ncbi.nlm.nih.gov/pubmed/20400958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2049
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