The Small GTPase RhoA Localizes to the Nucleus and Is Activated by Net1 and DNA Damage Signals

BACKGROUND: Rho GTPases control many cellular processes, including cell survival, gene expression and migration. Rho proteins reside mainly in the cytosol and are targeted to the plasma membrane (PM) upon specific activation by guanine nucleotide exchange factors (GEFs). Accordingly, most GEFs are a...

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Main Authors: Dubash, Adi D., Guilluy, Christophe, Srougi, Melissa C., Boulter, Etienne, Burridge, Keith, García-Mata, Rafael
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044755/
https://ncbi.nlm.nih.gov/pubmed/21390328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017380
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