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Measurement of Net Rate Constants from Enzyme Progress Curves without Curve Fitting

A method is described whereby net rate constants can be directly inferred from the progress curves of enzyme intermediates without the need for model specification, numerical analysis, curve fitting, or the steady-state approximation. Specifically, if an enzyme intermediate in an ultimately irrevers...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Ruszczycky, Mark W., Liu, Hung-wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910778/
https://ncbi.nlm.nih.gov/pubmed/31710808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00762
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