Discovery and Characterization of Halogenated Xanthene Inhibitors of DUSP5 as Potential Photodynamic Therapeutics

Dual specific phosphatases (DUSPs) are an important class of mitogen-activated protein kinase (MAPK) regulators, and are drug targets for treating vascular diseases. Previously we had shown that DUSP5 plays a role in embryonic vertebrate vascular patterning. Herein, we screened a library of FDA-appr...

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Detalhes bibliográficos
Publicado no:J Photochem Photobiol A Chem
Principais autores: Bongard, Robert D., Lepley, Michael, Gastonguay, Adam, Syrlybaeva, Raulia R., Talipov, Marat R., Lipinsky, Rachel A. Jones, Leigh, Noah R., Brahmbhatt, Jaladhi, Kutty, Raman, Rathore, Rajendra, Ramchandran, Ramani, Sem, Daniel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910256/
https://ncbi.nlm.nih.gov/pubmed/31839699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jphotochem.2019.01.005
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