Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

BACKGROUND: Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domain of DUSP5. METHODS: pNPP is a mimic of the phosphorylated tyrosine on the E...

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書誌詳細
出版年:BMC Biochem
主要な著者: Neumann, Terrence S., Span, Elise A., Kalous, Kelsey S., Bongard, Robert, Gastonguay, Adam, Lepley, Michael A., Kutty, Raman G., Nayak, Jaladhi, Bohl, Chris, Lange, Rachel G., Sarker, Majher I., Talipov, Marat R., Rathore, Rajendra, Ramchandran, Ramani, Sem, Daniel S.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545774/
https://ncbi.nlm.nih.gov/pubmed/26286528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-015-0048-3
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