Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

BACKGROUND: Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domain of DUSP5. METHODS: pNPP is a mimic of the phosphorylated tyrosine on the E...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:BMC Biochem
मुख्य लेखकों: Neumann, Terrence S., Span, Elise A., Kalous, Kelsey S., Bongard, Robert, Gastonguay, Adam, Lepley, Michael A., Kutty, Raman G., Nayak, Jaladhi, Bohl, Chris, Lange, Rachel G., Sarker, Majher I., Talipov, Marat R., Rathore, Rajendra, Ramchandran, Ramani, Sem, Daniel S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2015
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545774/
https://ncbi.nlm.nih.gov/pubmed/26286528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-015-0048-3
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