Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

BACKGROUND: Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domain of DUSP5. METHODS: pNPP is a mimic of the phosphorylated tyrosine on the E...

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Publicado en:BMC Biochem
Autores principales: Neumann, Terrence S., Span, Elise A., Kalous, Kelsey S., Bongard, Robert, Gastonguay, Adam, Lepley, Michael A., Kutty, Raman G., Nayak, Jaladhi, Bohl, Chris, Lange, Rachel G., Sarker, Majher I., Talipov, Marat R., Rathore, Rajendra, Ramchandran, Ramani, Sem, Daniel S.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545774/
https://ncbi.nlm.nih.gov/pubmed/26286528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-015-0048-3
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