Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

BACKGROUND: Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficult target...

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Detalhes bibliográficos
Publicado no:BMC Biochem
Main Authors: Bongard, Robert D., Lepley, Michael, Thakur, Khushabu, Talipov, Marat R., Nayak, Jaladhi, Lipinski, Rachel A. Jones, Bohl, Chris, Sweeney, Noreena, Ramchandran, Ramani, Rathore, Rajendra, Sem, Daniel S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452347/
https://ncbi.nlm.nih.gov/pubmed/28569147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-017-0083-3
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