Discovery and Characterization of Halogenated Xanthene Inhibitors of DUSP5 as Potential Photodynamic Therapeutics

Dual specific phosphatases (DUSPs) are an important class of mitogen-activated protein kinase (MAPK) regulators, and are drug targets for treating vascular diseases. Previously we had shown that DUSP5 plays a role in embryonic vertebrate vascular patterning. Herein, we screened a library of FDA-appr...

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Опубликовано в: :J Photochem Photobiol A Chem
Главные авторы: Bongard, Robert D., Lepley, Michael, Gastonguay, Adam, Syrlybaeva, Raulia R., Talipov, Marat R., Lipinsky, Rachel A. Jones, Leigh, Noah R., Brahmbhatt, Jaladhi, Kutty, Raman, Rathore, Rajendra, Ramchandran, Ramani, Sem, Daniel S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910256/
https://ncbi.nlm.nih.gov/pubmed/31839699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jphotochem.2019.01.005
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