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Intramuscular Allopregnanolone and Ganaxolone in a Mouse Model of Treatment Resistant Status Epilepticus

Allopregnanolone (5α-pregnan-3α-ol-20-one) and its synthetic 3β-methyl analog ganaxolone are positive allosteric modulators of synaptic and extrasynaptic GABA(A) receptors that exhibit antiseizure activity in diverse animal seizure models, including models of status epilepticus (SE). The two neuroac...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Epilepsia
Prif Awduron: Zolkowska, Dorota, Wu, Chun-Yi, Rogawski, Michael A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910080/
https://ncbi.nlm.nih.gov/pubmed/29453777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13999
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