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Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

RATIONALE: Abnormalities in excitatory/inhibitory neurotransmission are hypothesized to contribute to autism spectrum disorder (ASD) etiology. BTBR, an inbred mouse strain, displays social deficits and repetitive self-grooming, offering face validity to ASD diagnostic symptoms. Reduced GABAergic neu...

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Détails bibliographiques
Publié dans:Psychopharmacology (Berl)
Auteurs principaux: Kazdoba, Tatiana M., Hagerman, Randi J., Zolkowska, Dorota, Rogawski, Michael A., Crawley, Jacqueline N.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703522/
https://ncbi.nlm.nih.gov/pubmed/26525567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-015-4115-7
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