First‐in‐man allopregnanolone use in super‐refractory status epilepticus

Super‐refractory status epilepticus (SRSE) is associated with high morbidity and mortality. Treatment of SRSE is complicated by progressive cortical hyperexcitability believed to result in part from synaptic GABA receptor internalization and desensitization. Allopregnanolone, a neurosteroid that pos...

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Bibliografiske detaljer
Udgivet i:Ann Clin Transl Neurol
Main Authors: Vaitkevicius, Henrikas, Husain, Aatif M., Rosenthal, Eric S., Rosand, Jonathan, Bobb, Wendell, Reddy, Kiran, Rogawski, Michael A., Cole, Andrew J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Brief Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454395/
https://ncbi.nlm.nih.gov/pubmed/28589168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.408
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