First‐in‐man allopregnanolone use in super‐refractory status epilepticus

Super‐refractory status epilepticus (SRSE) is associated with high morbidity and mortality. Treatment of SRSE is complicated by progressive cortical hyperexcitability believed to result in part from synaptic GABA receptor internalization and desensitization. Allopregnanolone, a neurosteroid that pos...

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Dettagli Bibliografici
Pubblicato in:Ann Clin Transl Neurol
Autori principali: Vaitkevicius, Henrikas, Husain, Aatif M., Rosenthal, Eric S., Rosand, Jonathan, Bobb, Wendell, Reddy, Kiran, Rogawski, Michael A., Cole, Andrew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454395/
https://ncbi.nlm.nih.gov/pubmed/28589168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.408
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