First‐in‐man allopregnanolone use in super‐refractory status epilepticus

Super‐refractory status epilepticus (SRSE) is associated with high morbidity and mortality. Treatment of SRSE is complicated by progressive cortical hyperexcitability believed to result in part from synaptic GABA receptor internalization and desensitization. Allopregnanolone, a neurosteroid that pos...

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Vydáno v:Ann Clin Transl Neurol
Hlavní autoři: Vaitkevicius, Henrikas, Husain, Aatif M., Rosenthal, Eric S., Rosand, Jonathan, Bobb, Wendell, Reddy, Kiran, Rogawski, Michael A., Cole, Andrew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454395/
https://ncbi.nlm.nih.gov/pubmed/28589168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.408
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