Fenretinide-induced Apoptosis of Acute Myeloid Leukemia Cells via NR4A1 Translocation into Mitochondria and Bcl-2 Transformation

OBJECTIVE: Fenretinide is reported to induce NR4A1-associated apoptosis in several types of cancer cells. However, it remains unclear about its specific role and the underlying mechanism in acute myeloid leukemia (AML). Therefore, this study aimed to explore the role and mechanism of fenretinide-ind...

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Bibliografiske detaljer
Udgivet i:J Cancer
Main Authors: Xiong, Jie, Kuang, Xingyi, Lu, Tingting, Liu, Xu, Cheng, Bingqing, Wang, Weili, Wei, Danna, Li, Xinyao, Zhang, Zhaoyuan, Fang, Qin, Wu, Depei, Wang, Jishi
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909957/
https://ncbi.nlm.nih.gov/pubmed/31839811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.32167
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