AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia

Altered metabolism fuels 2 hallmark properties of cancer cells: unlimited proliferation and differentiation blockade. Adenosine monophosphate–activated protein kinase (AMPK) is a master regulator of bioenergetics crucial for glucose metabolism in acute myeloid leukemia (AML), and its inhibition dela...

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Vydáno v:Blood
Hlavní autoři: Jiang, Yajian, Hu, Tianyuan, Wang, Tao, Shi, Xiangguo, Kitano, Ayumi, Eagle, Kenneth, Hoegenauer, Kevin A., Konopleva, Marina Y., Lin, Charles Y., Young, Nicolas L., Nakada, Daisuke
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908829/
https://ncbi.nlm.nih.gov/pubmed/31697807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001076
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