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Amyloidogenicity and cytotoxicity of des-Lys-1 human amylin provides insight into amylin self-assembly and highlights the difficulties of defining amyloidogenicity

The polypeptide amylin is responsible for islet amyloid in type 2 diabetes, a process which contributes to β-cell death in the disease. The role of the N-terminal region of amylin in amyloid formation is relatively unexplored, although removal of the disulfide bridged loop between Cys-2 and Cys-7 ac...

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Bibliografski detalji
Izdano u:Protein Eng Des Sel
Glavni autori: Lee, Kyung-Hoon, Zhyvoloup, Alexander, Raleigh, Daniel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908818/
https://ncbi.nlm.nih.gov/pubmed/31768548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzz036
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