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Analysis of the Amyloidogenic Potential of Pufferfish (Takifugu rubripes) Islet Amyloid Polypeptide Highlights the Limitations of Thioflavin-T Assays and the Difficulties in Defining Amyloidogenicity

Islet amyloid polypeptide (IAPP, amylin) forms pancreatic amyloid in type-2 diabetes, a process that contributes to the loss of β-cell mass in the disease. IAPP has been found in all higher organisms examined, but not all species form amyloid and the ability to do so correlates with the primary sequ...

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Publicat a:Biochemistry
Autors principals: Wong, Amy G., Wu, Chun, Hannaberry, Eleni, Watson, Matthew D., Shea, Joan-Emma, Raleigh, Daniel P.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502355/
https://ncbi.nlm.nih.gov/pubmed/26694855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01107
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